RNA Details
Disease Name
idiopathic pulmonary fibrosis
Tissue
lung
RNA Symbol
Nox4
RNA ID
RNA Type
mRNA
Alteration Pattern
dysregulation
Species
mus musculus
Detection Methods
Dual-luciferase reporter assay; ISH etc.
Target
Tgfbr2; Nox4
Pathway
NA
PubMed ID
Title
MiR-9-5p suppresses pro-fibrogenic transformation of fibroblasts and prevents organ fibrosis by targeting NOX4 and TGFBR2
Year
2015
Function
"Transforming growth factor-B1 (TGF-B1) stimulates the production of NADPH oxidase 4 (NOX4)-dependent ROS, promoting lung fibrosis (LF). MiR-9-5p has an inhibitory effect on TGF-B receptor type II (TGFBR2) and NOX4 expression. Increased expression of miR-9-5p abrogates TGF-B1-dependent myofibroblast phenotypic transformation. In the mouse model of bleomycin-induced LF, miR-9-5p dramatically reduces fibrogenesis and inhibition of miR-9-5p prevents its anti-fibrotic effect both in vitro and in vivo. In lung specimens from patients with IPF, high levels of miR-9-5p are found. TGF-B1 induces miR-9-5p expression as a self-limiting homeostatic response."